The origin and mechanisms of human interictal epileptic discharges remain unclear. Here,
we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients
with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of …

Nineteen of 25 patients treated with systemic bleomycin therapy developed skin toxicities
such as infiltrated plaques, nodules, and bands on the hands, linear hyperpigmentation on
the trunk, and gangrene of the fingertips. The association of these changes with pulmonary …

Objective.—Diarrhea is an important cause of death among young children in both
developing and developed countries, but little is known about diarrheal deaths among
adults. In this study, we examined trends in diarrheal deaths among all age groups in the …

We present functional ultrasound (fUS), a method for imaging transient changes in blood
volume in the whole brain at better spatiotemporal resolution than with other functional brain
imaging modalities. fUS uses plane-wave illumination at high frame rate and can measure …

The mechanisms involved in the transition to an epileptic seizure remain unclear. To
examine them, we used tissue slices from human subjects with mesial temporal lobe
epilepsies. Ictal-like discharges were induced in the subiculum by increasing excitability …

METHODS Hippocampal slices were prepared according to local regulations from guinea-
pigs (weight 100—200g) anaesthetised by intraperitoneal injection of ketamine (200 mg
kg¢) and chloral hydrate (800 mg kg¢). Animals were perfused intracardially with a cold (3 …

Hippocampal population discharges such as sharp waves, epileptiform firing, and GDPs
recur at long and variable intervals. The mechanisms for their precise timing are not well
understood. Here, we show that population bursts in the disinhibited CA3 region are initiated …

Ultrafast ultrasonic imaging is a rapidly developing field based on the unfocused
transmission of plane or diverging ultrasound waves. This recent approach to ultrasound
imaging leads to a large increase in raw ultrasound data available per acquisition. Bigger …

Hemodynamic changes in the brain are often used as surrogates of neuronal activity to infer
the loci of brain activity. A major limitation of conventional Doppler ultrasound for the
imaging of these changes is that it is not sensitive enough to detect the blood flow in small …

Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal
sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions,
may contribute to the human pathology. A review of changes in cellular and synaptic …