G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the
physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from
voluntary movement and reward to hormonal regulation and hypertension. Pharmacological …

Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine
receptors are the best-established target of antipsychotic drugs. Here we show that D2 class-
receptor-mediated Akt regulation involves the formation of signaling complexes containing β …

Dopamine (DA) is a neurotransmitter involved in the control of locomotion, emotion,
cognition, and reward. Administration of lithium salts is known to inhibit DA-associated
behaviors in experimental animal models through unknown mechanisms. Here, we used a …

Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan
hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a
functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the …

Dysregulation of central serotonin neurotransmission has been widely suspected as an
important contributor to major depression. Here, we identify a (G1463A) single nucleotide
polymorphism (SNP) in the rate-limiting enzyme of neuronal serotonin synthesis, human …

Psychotropic drugs acting on monoamine neurotransmission are major pharmacological
treatments for neuropsychiatric conditions such as schizophrenia, depression, bipolar
disorder, Tourette syndrome, ADHD, and Alzheimer disease. Independent lines of research …

Drugs that act on dopamine neurotransmission are important tools for the management of
multiple neuropsychiatric disorders. Classically, dopamine receptors have been shown to
regulate cAMP–PKA (protein kinase A) and Ca 2+ pathways through G-protein-mediated …

Besides their role in desensitization, β-arrestin 1 and 2 promote the formation of signaling
complexes allowing G protein-coupled receptors (GPCR) to signal independently from G
proteins. Here we show that lithium, a pharmacological agent used for the management of …

Dysregulation of brain serotonin (5-HT) neurotransmission is thought to underlie mental
conditions as diverse as depression, anxiety disorders, bipolar disorder, autism, and
schizophrenia. Despite treatment of these conditions with serotonergic drugs, the molecular …

To identify the molecular mechanisms underlying psychostimulant-elicited plasticity in the
brain reward system, we undertook a phenotype-driven approach using genome-wide
microarray profiling of striatal transcripts from three genetic and one pharmacological mouse …