Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture 1, 2, 3, 4. We report here a comprehensive analysis of
transcriptome dynamics from oocyte to morula in both human and mouse embryos, using …

Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility,
affecting 5–10% of females of reproductive age. Currently, little is known about the changes
in whole proteins between PCOS and normal ovaries. In the present study, a proteomic …

Objective: To determine whether women with idiopathic hypergonadotropic amenorrhea
have unique alterations in the FSH receptor gene that could account for reduced activity.
Design: Compare FSH receptor genes of affected women with normally menstruating control …

Polycystic ovarian syndrome (PCOS) is a heterogeneous syndrome associated with follicle
growth arrest, minimal granulosa cell proliferation, dysregulated sex hormone profile,
hyperthecosis, and insulin resistance. Using a 5α-dihydrotestosterone (DHT)-induced rat …

Mammalian spermatozoa contain a complex population of mRNAs, some of which have
been demonstrated to be translated de novo by mitochondrial‐type ribosomes using D‐
chloramphenicol (CP), a specific inhibitor of mitochondrial translation. However, little is …

抄録 The anticancer agent genistein inhibits cell growth of tumor cell lines from various
malignancies. In our study, we investigated the effectiveness of combined treatment of
ionizing radiation (IR) with genistein on cervical HeLa cells and its possible mechanism. It …

Orphan nuclear receptor NR4A1, a member of the nuclear receptor superfamily, is widely
expressed in different cell types and mediates diverse biological processes. Recent
emerging evidence suggests that NR4A1 is involved in the transcriptional regulation of …

In the present study, we have investigated the cellular mechanisms of androgen-induced
antral follicular growth arrest and the possible involvement of chemerin and its receptor
chemokine-like receptor 1 (CMKLR1) in this process, using a chronically androgenized rat …

Abstract H+-translocating pyrophosphatases (H+-PPases) are active proton transporters that
establish a proton gradient across the endomembrane by means of pyrophosphate (PP i)
hydrolysis 1, 2. H+-PPases are found primarily as homodimers in the vacuolar membrane of …

When infertile women undergoing IVF or intracytoplasmic sperm injection (ICSI) have more
than 20 mature oocytes retrieved, at least 15 oocytes are inseminated by their husband's
spermatozoa. The extra oocytes are cryopreserved by vitrification. If the patients became …