S100A8 and S100A9 are small calcium-binding proteins that are highly expressed in
neutrophil and monocyte cytosol and are found at high levels in the extracellular milieu
during inflammatory conditions. Although reports have proposed a proinflammatory role for …

Recently, proinflammatory activities had been described for S100A8 and S100A9, two
proteins found at inflammatory sites and within the neutrophil cytoplasm. In this study, we
investigated the role of these proteins in neutrophil migration in vivo in response to LPS …

A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …

Objective To examine the role of chemokines, S100A8, and S100A9 in neutrophil
accumulation induced by the causative agent of gout, monosodium urate monohydrate
(MSU) crystals. Methods MSU crystal–induced neutrophil migration was studied in the …

During malaria infection, high levels of proinflammatory molecules (eg, cytokines,
chemokines) correlate with disease severity. Even if their role as activators of the host
immune response has been studied, the direct contribution of hemozoin (HZ), a parasite …

The neutrophil cytoplasmic protein S100A8/A9 (along with S100A8 and S100A9) is
chemotactic and stimulates neutrophil adhesion by activating the β2‐integrin CD11b/CD18.
It is also essential to neutrophil migration in vivo in response to monosodium urate …

We investigated the proinflammatory activities of S100A12 in the context of synovial
inflammation. S100A12 levels were increased in the synovial fluids and plasma of patients
with gout, rheumatoid arthritis, psoriatic arthritis, and undetectable in osteoarthritis, a …

Neutrophil migration from the blood to inflammatory sites follows a cascade of events, in
which adhesion to endothelial cells and extracellular matrix proteins is essential. S100A8,
S100A9, and S100A12 are small abundant proteins found in human neutrophil cytosol and …

Many chemicals of environmental concern are known to alter the immune system and are
considered toxic molecules because they affect immune cell functions. Inflammation related
to environmental chemical exposure, however, is poorly documented, except that from air …

Expression of pili and associated proteins is an important means of host invasion by
bacterial pathogens. Recent evidence has suggested that the binding of Pseudomonas
aeruginosa through nonpilus adhesins may also be important in respiratory diseases, since …