T-helper cells that produce interleukin-17 (TH 17 cells) are a recently identified CD4+ T-cell
subset with characterized pathological roles in autoimmune diseases 1, 2, 3. The nuclear
receptors retinoic-acid-receptor-related orphan receptors α and γt (RORα and RORγt …

Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular
health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-
ERB-β have an integral role in regulating the expression of core clock proteins driving …

Background Human hypomorphic nuclear factor-κB essential modulator (NEMO) mutations
cause diverse clinical and immunologic phenotypes, but understanding of their scope and
mechanistic links to immune function and genotype is incomplete. Objective We created and …

Abstract The Nuclear Factor-kappa B (NF-κB) family of transcription factors regulates the
expression of a wide range of genes critical for immune and inflammatory responses, cell
survival, immune development, and cell proliferation. Dysregulated NF-κB activity occurs in …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

The retinoic acid receptor-related orphan receptors α and γ (RORα (NR1F1) and RORγ
(NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of
development, metabolism, and immune function. Cholesterol and cholesterol sulfate have …

Retinoic acid receptor-related orphan receptors (RORs) regulate a variety of physiological
processes including hepatic gluconeogenesis, lipid metabolism, circadian rhythm, and
immune function. Here we present the first high-affinity synthetic ligand for both RORα and …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as
targets for development of myriad drugs that target a range of disorders. Classically defined …

The nuclear hormone receptor, REV-ERB, plays an essential role in adipogenesis. Rev-erb
α expression is induced in 3T3-L1 cells during adipogenesis, and overexpression of this
receptor leads to expression of adipogenic genes. We recently demonstrated that the …

Activation of NF-κB by the proinflammatory cytokines TNF and IL-1 requires the IκB kinase
(IKK) complex that contains two kinases named IKKα and IKKβ and a critical regulatory
subunit named NEMO. Although we previously demonstrated that NEMO associates with …