Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture 1, 2, 3, 4. We report here a comprehensive analysis of
transcriptome dynamics from oocyte to morula in both human and mouse embryos, using …

Recent advances in gene editing technology have introduced the potential for application of
mutagenesis approaches in nonhuman primates to model human development and
disease. Here we report successful TALEN-mediated mutagenesis of an X-linked, Rett …

Neurofibrillary tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a
common feature of numerous aging-related neurodegenerative diseases, including
Alzheimer's disease (AD). However, the molecular mechanisms mediating tau truncation …

The scarcity of tissue-specific stem cells and the complexity of their surrounding environment
have made molecular characterization of these cells particularly challenging. Through single-
cell transcriptome and weighted gene co-expression network analysis (WGCNA), we …

The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor
protein (APP), is a neuropathological hallmark of Alzheimer's disease (AD). Despite age
being the greatest risk factor for AD, the molecular mechanisms linking ageing to APP …

Study Design. Glucocorticoid with low calcium and phosphorus intake induces osteopenia in
cancellous bone of sheep. Objective. To validate a large animal model for spine fusion and
biomaterial research. Summary of Background Data. A variety of ovariectomized animals …

DNA methylation is known to regulate cell differentiation and neuronal function in vivo. Here
we examined whether deficiency of a de novo DNA methyltransferase, Dnmt3a, affects in
vitro differentiation of mouse embryonic stem cells (mESCs) to neuronal and glial cell …

Recent genome‐wide association studies (GWAS) have reported multiple genetic variations
at 5p15. 33 (TERT‐CLPTM1L) associated with risk of lung cancer. However, most of the
associated variations identified by GWAS thus far are unlikely to be the actual causal …

Spinal cord injury (SCI) is a serious injury of the central nervous system and up until now
there is no evident effective treatment for SCI. Axonal regeneration is the only way to restore
functions after serious SCI that interrupt the long tracts mediating motor and sensory …

The minimally invasive Oxford unicompartmental knee arthroplasty (UKA) is a demanding
procedure but has many advantages compared with total knee arthroplasty (TKA). The aim
of this observational study was to investigate the learning curve of one experienced surgeon …