We developed a new, silicon-based peptide array for a broad range of biological
applications, including potential development as a real-time point-of-care platform. We used
photolithography on silicon wafers to synthesize microarrays (Intel arrays) that contained …

Over the last decade, field-effect transistors (FETs) with nanoscale dimensions have
emerged as possible label-free biological and chemical sensors capable of highly sensitive
detection of various entities and processes. While significant progress has been made …

We introduce a label-free approach for sensing polymerase reactions on deoxyribonucleic
acid (DNA) using a chelator-modified silicon-on-insulator field-effect transistor (SOI-FET) that
exhibits selective and reversible electrical response to pyrophosphate anions. The chemical …

A new pyrophosphate (PPi) chelator was designed for surface-sensitive electrical detection
of biomolecular reactions. This article describes the synthesis of the PPi-selective receptor,
its surface immobilization and application to label-free electrical detection on a silicon-based …

In this paper, we have demonstrated a highly scalable all-electronic approach towards DNA
sequencing using CMOS readout electronics coupled with post-processed nanogap
transducers. While this test chip demonstrated a small array of 8,192 pixels, a 25mm 2 chip …

The mechanisms underlying development of ribonucleoprotein (RNP) autoantibodies are
unclear. The U1-70K protein is the predominant target of RNP autoantibodies, and the RNA
binding domain has been shown to be the immunodominant autoantigenic region of U1 …

Various embodiments provide devices, methods, and systems for high throughput
biomolecule detection using transducer arrays. In one embodiment, a transducer array
made up of transducer elements may be used to detect byproducts from chemical reactions …

Autoantibodies are a hallmark of autoimmune diseases such as lupus and have the
potential to be used as biomarkers for diverse diseases, including immunodeficiency,
infectious disease, and cancer. More precise detection of antibodies to specific targets is …

Nanopore based DNA sequencers require integration of miniaturized electrodes and
amplifier electronics in close proximity to the nanopores in a CMOS platform. This will
facilitate portability, enable faster analysis, and improve sensing performance. Here we …

Various embodiments provide devices, methods, and systems for high throughput
biomolecule detections using transducer arrays. In one embodiment, a transducer array
made up of a plurality of transducer elements may be used to detect byproducts from …