The KRAS oncogene product is considered a major target in anticancer drug discovery 1, 2,
3. However, direct interference with KRAS signalling has not yet led to clinically useful drugs
3, 4, 5, 6, 7, 8. Correct localization and signalling by farnesylated KRAS is regulated by the …

Page 1. Int J Game Theory (2007) 35:557–568 DOI 10.1007/s00182-006-0068-8 ORIGINAL
PAPER The Shapley value of exact assignment games Maike Hoffmann · Peter Sudhölter
Published online: 2 February 2007 © Springer-Verlag 2007 Abstract We prove that the Shapley …

Fertilization of the ocean by adding iron compounds has induced diatom-dominated
phytoplankton blooms accompanied by considerable carbon dioxide drawdown in the
ocean surface layer. However, because the fate of bloom biomass could not be adequately …

Many studies have detailed the repressive effects of DNA methylation on gene expression.
However, the mechanisms that promote active demethylation are just beginning to emerge.
Here, we show that methylation of the rDNA promoter is a dynamic and reversible process …

Deficiency in γδ T cells aggravates colitis in animal models suggesting that γδ T cells have
regulatory properties. Therefore, proliferation, suppression and cytokine secretion of human
γδ T cells were determined in vitro. Human peripheral γδ T cells were isolated from the …

Reports of decreased serum 25-hydroxyvitamin D (25-OHD) and altered bone metabolism
associated with antiepileptic drug (AED) treatment are inconsistent and predominantly
restricted to adults. In this cross-sectional observational study, the aim was to evaluate the …

Proteomics-based clinical studies have been shown to be promising strategies for the
discovery of novel biomarkers of a particular disease. Here, we present a study of
hepatocellular carcinoma (HCC) that combines complementary gel-based and LC-MS …

Purpose Although the outcome of patients with HIV-related Hodgkin lymphoma (HIV-HL) has
markedly improved since the introduction of combined antiretroviral therapy, standard
therapy is still poorly defined. This prospective study investigates a stage-and risk-adapted …

During the primary response, the commitment of the CD8+ T cell to Blimp-1 expression and
the terminal differentiation that Blimp-1 induces must be timed so as not to impair the
process of clonal expansion. We determined whether the Hippo pathway, which links cell …

Multi-OMICS approaches aim on the integration of quantitative data obtained for different
biological molecules in order to understand their interrelation and the functioning of larger
systems. This paper deals with several data integration and data processing issues that …