© Giles Atkinson, Simon Dietz, Eric Neumayer and Matthew Agarwala 2014 All rights
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Abstract The human genome holds an extraordinary trove of information about human
development, physiology, medicine and evolution. Here we report the results of an
international collaboration to produce and make freely available a draft sequence of the ...

Abstract The sequence of the mouse genome is a key informational tool for understanding
the contents of the human genome and a key experimental tool for biomedical research.
Here, we report the results of an international collaboration to produce a high-quality draft ...

Background A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the
head and neck compared induction chemotherapy with docetaxel plus cisplatin and
fluorouracil (TPF) with cisplatin and fluorouracil (PF), followed by chemoradiotherapy.

Background In a phase 1 dose-escalation study, combined inhibition of T-cell checkpoint
pathways by nivolumab and ipilimumab was associated with a high rate of objective
response, including complete responses, among patients with advanced melanoma.

Abstract High-throughput sequencing technology enables population-level surveys of
human genomic variation. Here, we examine the joint allele frequency distributions across
continental human populations and present an approach for combining complementary ...

We direct your readers' attention to the principles and guidelines (Supplementary
Guidelines) developed by the Next-generation Sequencing: Standardization of Clinical
Testing (Nex-StoCT) workgroup. These guidelines represent initial steps to ensure that ...

Background: Fosbretabulin is a novel vascular-disrupting agent that has antitumor activity
against anaplastic thyroid cancer (ATC) cell lines, xenografts, and demonstrable efficacy in a
phase I trial. This phase II study determined the efficacy and safety of fosbretabulin in ...

The availability of a high quality human genome assembly has revolutionized biomedical
research. Genomics has now entered the realm of clinical genetics, with many groups using
either whole genome sequencing [1, 2] or whole exome sequencing [3] to identify variants ...

The proposition that an extended net–or genuine–saving has a central place in any portfolio
of indicators purporting to measure the sustainability of development appears now to be
firmly established (UNECE 2007; StIglItz, SEN aNd FItOUSSI 2009; WORld BaNk 2010). ...