Resveratrol is a natural compound that affects energy metabolism and mitochondrial
function and serves as a calorie restriction mimetic, at least in animal models of obesity.
Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) …

Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations
as a major contributor to the development of insulin resistance and type 2 diabetes. In this
article we will provide an integrative view on the interrelation between decreased oxidative …

Objective A lower in vivo mitochondrial function has been reported in (first-degree relatives
(FDR) of) diabetic patients (T2DM). The nature of this reduction is unknown. Here we tested
the hypothesis that a lower intrinsic mitochondrial respiratory capacity may underlie lower in …

Objective-Mitochondrial dysfunction and fat accumulation in skeletal muscle (IMCL) has
been linked to development of type 2 diabetes. We examined if exercise training could
restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes (T2D) …

SPECIFIC AIMS Transcription factors and their target genes, especially those involved with
PPAR families, can be regulated directly via increases in free fatty acids (FA). As physical
exercise stimulates lipolysis and increases circulatory FFA levels, the effect of exercise per …

The physiological function of the human uncoupling protein 3 UCP3, which was discovered
in 1997, is unknown. Here we evaluate the available data on human UCP3 expression and
show that UCP3 is up-regulated in situations where fatty acid delivery to the mitochondria …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

Fat can be stored not only in adipose tissue but also in other tissues such as skeletal
muscle. Fat droplets accumulated in skeletal muscle [intramyocellular lipids (IMCLs)] can be
quantified by different methods, all with advantages and drawbacks. Here, we briefly review …

Most research on creatine has focused on short-term creatine loading and its effect on high-
intensity performance capacity. Some studies have investigated the effect of prolonged
creatine use during strength training. However, studies on the effects of prolonged creatine …

Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the
development of insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial
capacity will contribute to the accumulation of lipid intermediates, desensitizing insulin …