Major advances in the identification of genes implicated in idiopathic epilepsy have been
made. Generalized epilepsy with febrile seizures plus (GEFS+), benign familial neonatal
convulsions and nocturnal frontal lobe epilepsy, three autosomal dominant idiopathic …

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here,
we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients
with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of …

Epileptic seizures are a principal brain dysfunction with important public health implications,
as they affect 0.8% of humans. Many of these patients (20%) are resistant to treatment with
drugs 1. The ability to anticipate the onset of seizures in such cases would permit clinical …

Background New methods derived from non-linear analysis of intracranial recordings permit
the anticipation of an epileptic seizure several minutes before the seizure. Nevertheless,
anticipation of seizures based on standard scalpelectroencephalographical (EEG) signals …

Changes in chloride (Cl−) homeostasis may be involved in the generation of some epileptic
activities. In this study, we asked whether Cl− homeostasis, and thus GABAergic signaling, is
altered in tissue from patients with mesial temporal lobe epilepsy associated with …

PURPOSE To evaluate the accuracy of hippocampal and amygdala volume measurements
in diagnosing patients in the early stages of Alzheimer disease. METHODS Measurements
of the hippocampal formation, amygdala, amygdalohippocampal complex (the two …

We compared conscious and nonconscious processing of briefly flashed words using a
visual masking procedure while recording intracranial electroencephalogram (iEEG) in ten
patients. Nonconscious processing of masked words was observed in multiple cortical …

IN a previous publication we showed that non-linear analysis can extract spatio-temporal
changes of brain electrical activity prior to epileptic seizures. Here we describe a new
method to analyze this long-term nonstationarity in the EEG by a measure of dynamical …

Models of the “visual word form system” postulate that a left occipitotemporal region
implements the automatic visual word recognition required for efficient reading. This theory
was assessed in a patient in whom reading was explored with behavioral measures, fMRI …

Background The association between epilepsy and autism is consistently reported, with a
wide range of prevalence rates. This may be attributed to the heterogeneity of the samples
with respect to age, comorbidity, sex, and intellectual disability (ID). We aimed to compare …