Background The candidate vaccines against malaria are poorly immunogenic and thus have
been ineffective in preventing infection. We developed a vaccine based on the
circumsporozoite protein of Plasmodium falciparum that incorporates adjuvants selected to …

Background An effective prophylactic vaccine would help control the spread of genital
herpes. Methods We conducted two double-blind, randomized trials of a herpes simplex
virus type 2 (HSV-2) glycoprotein-D–subunit vaccine with alum and 3-O-deacylated …

Already, devices that harness electrical impulses are used to treat disease. Pacemakers and
defibrillators save millions of lives each year; deep-brain stimulation dramatically improves
the quality of life for people with Parkinson's disease and depress ion; sacral-nerve …

Abstract The RTS, S/SBAS2 vaccine confers sterile protection against Plasmodium
falciparum sporozoite challenge. The mechanisms underlying this are of great interest, yet
little is known about the immune effector mechanisms induced by this vaccine. The immune …

3-O-deacylated monophosphoryl lipid A (or 3 De-O-acylated monophosphoryl lipid A) has formerly
been termed 3D-MPL or d3-MPL to indicate that position 3 of the reducing end glucosamine
is de-O-acylated. For preparation, see GB 2 220 211 A. Chemically it is a mixture of 3-deacylated …

In two recent clinical trials, a vaccine containing herpes simplex virus (HSV) type 2
glycoprotein D (gD2) and a novel adjuvant AS04 comprising alum (Al) and 3-deactylated
monophosphoryl lipid A (3-dMPL) afforded HSV-seronegative women significant protection …

We determined the prevalence of herpes simplex virus (HSV) and cytomegalovirus (CMV)
antibodies in a cohort of adolescents 12 to 22 years of age in anticipation of the
development of vaccines to control HSV and CMV infections. For the overall study …

Cytomegalovirus (CMV) is the most common congenital viral infection, but little is known
about the protective immune mechanisms. The guinea pig (gp) model of congenital CMV
was used to evaluate the effects of passive antibody given to pregnant dams on pup …

This study was designed to evaluate the efficacy and mechanisms of protection mediated by
recombinant vaccinia viruses encoding immediate-early (IE) proteins of herpes simplex virus
type 2 (HSV-2). Three mouse strains were immunized against the IE proteins ICP27, ICP0 …

The ability of monophosphoryl lipid A (MPL), QS-21, and alum to alter the immunologic
response to immunization with respiratory syncytial virus a chimeric FG construct (FG)
subunit vaccine was examined in BALB c mice. FG MPL, FG/alum, and FG/MPL/QS-21 …