Brain stimulation methods are indispensable to the study of brain function. They have also
proven effective for treating some neurological disorders. Historically used for medical
imaging, ultrasound (US) has recently been shown to be capable of noninvasively …

From the Departments of Medicine, Pathology, Radiology, and Biostatistics and
Epidemiology, Memorial Sloan-Kettering Cancer Center; Rockefeller University, New York,
NY; Department of Internal Medicine, Division of Hematology/Oncology, University of …

Multiple genetic variants have been associated with adult obesity and a few with severe
obesity in childhood; however, less progress has been made in establishing genetic
influences on common early-onset obesity. We performed a North American, Australian and …

Regulation of contraction in skeletal muscle occurs through calcium binding to the protein
troponin C. The solution structures of the regulatory domain of apo and calcium-loaded
troponin C have been determined by multinuclear, multidimensional nuclear magnetic …

The interaction of troponin-C (TnC) with troponin-I (TnI) plays a central role in skeletal and
cardiac muscle contraction. We have recently shown that the binding of Ca2+ to cardiac TnC
(cTnC) does not induce an “opening” of the regulatory domain in order to interact with cTnI …

The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect
different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator
of cardiac muscle contraction, possesses different functional and Ca 2+-binding properties …

While calcium binding to troponin C (TnC) triggers the contraction of both skeletal and
cardiac muscle, there is clear evidence that different mechanisms may be involved. For
example, activation of heart myofilaments occurs with binding to a single regulatory site on …

Emerging evidence suggests that gut microbiota is critical in the maintenance of
physiological homeostasis. This study was designed to test the hypothesis that dysbiosis in
gut microbiota is associated with hypertension because genetic, environmental, and dietary …

The backbone resonance assignments have been completed for the apo (1H and 15N) and
calcium‐loaded (1H, 15N, and 13C) regulatory N‐domain of chicken skeletal troponin‐C (1–
90), using multidimensional homonuclear and heteronuclear NMR spectroscopy. The …

Cowden disease (CD) is an autosomal dominant cancer predisposition syndrome
associated with an elevated risk for tumours of the breast, thyroid and skin1–2. Lhermitte-
Duclos disease (LDD) cosegregates with a subset of CD families and is associated with …