User profiles for author:Nicolas author:Doyon
 | nicolas doyonprofesseur de mathématique, Université Laval Verified email at mat.ulaval.ca Cited by 566 |
Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
[HTML][HTML] Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis
Chloride homeostasis is a critical determinant of the strength and robustness of inhibition
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl−
gradient is relatively straightforward to understand, but how dynamic interplay between Cl …
mediated by GABAA receptors (GABAARs). The impact of changes in steady state Cl−
gradient is relatively straightforward to understand, but how dynamic interplay between Cl …
[HTML][HTML] Inhibitory synaptic plasticity: spike timing-dependence and putative network function
While the plasticity of excitatory synaptic connections in the brain has been widely studied,
the plasticity of inhibitory connections is much less understood. Here, we present recent
experimental and theoretical□ ndings concerning the rules of spike timing-dependent …
the plasticity of inhibitory connections is much less understood. Here, we present recent
experimental and theoretical□ ndings concerning the rules of spike timing-dependent …
[HTML][HTML] Chloride regulation: a dynamic equilibrium crucial for synaptic inhibition
Fast synaptic inhibition relies on tight regulation of intracellular Cl−. Chloride dysregulation
is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition,
the consequences of Cl− dysregulation are multifaceted and best understood in terms of a …
is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition,
the consequences of Cl− dysregulation are multifaceted and best understood in terms of a …
Treating pathological pain: is KCC2 the key to the gate?
“One potential way of treating neuropathic pain is to restore proper inhibitory pathways in the
CNS… a promising promising analgesic strategy is to enhance KCC2 activity not only to
restore EGABA to its normal value, but also to prevent activity-dependant Cl …
CNS… a promising promising analgesic strategy is to enhance KCC2 activity not only to
restore EGABA to its normal value, but also to prevent activity-dependant Cl …
Allosteric modulation of metabotropic glutamate receptors by chloride ions
…, HO Bertrand, I Brabet, Y De Koninck, N Doyon… - The FASEB …, 2015 - fasebj.org
Metabotropic glutamate receptors (mGluRs) play key roles in the modulation of many
synapses. Chloride (Cl−) is known to directly bind and regulate the function of different
actors of neuronal activity, and several studies have pointed to the possible modulation of …
synapses. Chloride (Cl−) is known to directly bind and regulate the function of different
actors of neuronal activity, and several studies have pointed to the possible modulation of …
[HTML][HTML] Mild KCC2 Hypofunction causes inconspicuous chloride dysregulation that degrades neural coding
Disinhibition caused by Cl-dysregulation is implicated in several neurological disorders.
This form of disinhibition, which stems primarily from impaired Cl-extrusion through the co-
transporter KCC2, is typically identified by a depolarizing shift in GABA reversal potential …
This form of disinhibition, which stems primarily from impaired Cl-extrusion through the co-
transporter KCC2, is typically identified by a depolarizing shift in GABA reversal potential …
[CITATION][C] On the counting function for the Niven numbers
JM De Koninck, N Doyon, I Kátai - Acta Arithmetica, 2003 - eudml.org
Jean-Marie De Koninck, Nicolas Doyon, and Imre Kátai. "On the counting function for the Niven
numbers." Acta Arithmetica 106.3 (2003): 265-275. <http://eudml.org/doc/278575> … You must
be logged in to post comments … To embed these notes on your page include the following …
numbers." Acta Arithmetica 106.3 (2003): 265-275. <http://eudml.org/doc/278575> … You must
be logged in to post comments … To embed these notes on your page include the following …
[PDF][PDF] On the number of Niven numbers up to x
JM DeKoninck, N Doyon - Fibonacci Quarterly, 2003 - fq.math.ca
A positive integer n is said to be a Niven number (or a Harshad number) if it is divisible by the
sum of its (decimal) digits. For instance, 153 is a Niven number since 9 divides 153, while 154
is not* Let N(x) denote the number of Niven numbers < x. Using a computer, one can obtain the …
sum of its (decimal) digits. For instance, 153 is a Niven number since 9 divides 153, while 154
is not* Let N(x) denote the number of Niven numbers < x. Using a computer, one can obtain the …
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV-1 from latently infected cells
K Huber, G Doyon, J Plaks, E Fyne, JW Mellors… - Journal of Biological …, 2011 - ASBMB
Deacetylation of histone proteins at the HIV-1 long terminal repeat (LTR) by histone
deactylases (HDACs) can promote transcriptional repression and virus latency. As such,
HDAC inhibitors (HDACI) could be used to deplete reservoirs of persistent, quiescent HIV-1 …
deactylases (HDACs) can promote transcriptional repression and virus latency. As such,
HDAC inhibitors (HDACI) could be used to deplete reservoirs of persistent, quiescent HIV-1 …
