Dynamic regulation of diverse nuclear processes is intimately linked to covalent
modifications of chromatin 1, 2. Much attention has focused on methylation at lysine 4 of
histone H3 (H3K4), owing to its association with euchromatic genomic regions 3, 4. H3K4 …

The Sir2 deacetylase regulates chromatin silencing and lifespan in Saccharomyces
cerevisiae 1, 2. In mice, deficiency for the Sir2 family member SIRT6 leads to a shortened
lifespan and a premature ageing-like phenotype 3. However, the molecular mechanisms of …

Covalent modifications of histone tails have a key role in regulating chromatin structure and
controlling transcriptional activity. In eukaryotes, histone H3 trimethylated at lysine 4
(H3K4me3) is associated with active chromatin and gene expression 1, 2, 3, 4. We recently …

Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways.
However, their functions in the nucleus are unclear, as specific nuclear receptors for
PtdInsPs have not been identified. Here, we show that ING2, a candidate tumor suppressor …

Nuclear processes such as transcription, DNA replication and recombination are
dynamically regulated by chromatin structure. Eukaryotic transcription is known to be
regulated by chromatin-associated proteins containing conserved protein domains that …

Histone methylation is crucial for regulating chromatin structure, gene transcription and the
epigenetic state of the cell. LSD1 is a lysine-specific histone demethylase that represses
transcription by demethylating histone H3 on lysine 4 (ref. 1). The LSD1 complex contains a …

Reversible covalent methylation of lysine residues on histone proteins constitutes a principal
molecular mechanism that links chromatin states to diverse biological outcomes. Recently,
lysine methylation has been observed on nonhistone proteins, suggesting broad cellular …

Here, we investigate the mechanism and function of LKB1, a Ser/Thr kinase mutated in
Peutz-Jegher syndrome (PJS). We demonstrate that LKB1 physically associates with p53
and regulates specific p53-dependent apoptosis pathways. LKB1 protein is present in both …

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability,
metabolism and ageing 1, 2. SIRT7 is a mammalian sirtuin whose biochemical activity,
molecular targets and physiological functions have been unclear. Here we show that SIRT7 …

The plasticity of ageing suggests that longevity may be controlled epigenetically by specific
alterations in chromatin state. The link between chromatin and ageing has mostly focused
on histone deacetylation by the Sir2 family 1, 2, but less is known about the role of other …