Background Studies in animals indicate that brown adipose tissue is important in the
regulation of body weight, and it is possible that individual variation in adaptive
thermogenesis can be attributed to variations in the amount or activity of brown adipose …

Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against
hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat:
classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that …

Resveratrol is a natural compound that affects energy metabolism and mitochondrial
function and serves as a calorie restriction mimetic, at least in animal models of obesity.
Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) …

In recent years, it has been shown that humans have active brown adipose tissue (BAT)
depots, raising the question of whether activation and recruitment of BAT can be a target to
counterbalance the current obesity pandemic. Here, we show that a 10-day cold acclimation …

Recent evidence points toward decreased oxidative capacity and mitochondrial aberrations
as a major contributor to the development of insulin resistance and type 2 diabetes. In this
article we will provide an integrative view on the interrelation between decreased oxidative …

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that
regulate genes involved in energy metabolism and inflammation. For biological activity,
PPARs require cognate lipid ligands, heterodimerization with retinoic X receptors, and …

The UCP2–UCP3 gene cluster maps to chromosome 11q13 in humans, and polymorphisms
in these genes may contribute to obesity through effects on energy metabolism. DNA
sequencing of UCP2 and UCP3 revealed three polymorphisms informative for association …

Objective: To examine the muscular uncoupling protein expression 2 (UCP2) and UCP3
gene expression in morbid obese subjects before and after bariatric surgery [bilio‐
pancreatic diversion (BPD)]. Research Methods and Procedures: Eleven obese subjects …

The prevalence of obesity is increasing in westernized societies. In the USA the age-
adjusted prevalence of BMI≫ 30 kg/m 2 increased between 1960 and 1994 from 13% to
23% for people over 20 years of age. This increase in the prevalence of obesity has been …

Background Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to
increase energy expenditure is suggested as a possible therapeutic target for the treatment
of obesity. We have recently shown high prevalence of BAT in adult humans, which was …