To test the hypothesis whether or not dobutamine or dopamine infusion increases gastric
mucosal perfusion, a prospective randomized crossover trial was conducted on 10 septic
patients in the intensive care unit of a university hospital. Systemic hemodynamic, oxygen …

OBJECTIVE: To determine whether correction of acidemia using bicarbonate improves
hemodynamic variables and tissue oxygenation in patients with lactic acidosis. DESIGN:
Prospective, randomized, blinded, cross over study. Each patient sequentially received …

The glycocalyx constitutes the first line of the blood tissue interface and is thus involved in
many physiological processes, deregulation of which may lead to microvascular dysfunction.
Because administration of LPS is accompanied by severe microvascular dysfunction, the …

Despite intensive therapy, severe septic shock is commonly associated with myocardial
dysfunction and death in humans. No new therapies have proven efficiency against
cardiovascular alterations in sepsis. Here, we addressed the question of a beneficial effect …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in
biological systems have emerged as a potential adjunctive therapy for sepsis via their
antioxidant, anti-inflammatory, and antiapoptotic effects. The role of CO in regulation of …

Objectives The purpose of this study was to test whether mitochondrial dysfunction is
causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation
and perforation. Inhibition of mitochondrial permeability transition was achieved by means of …

Objectives The aim of this study was to test whether peroxynitrite neutralizers would reduce
peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation
in endotoxin-treated rats. Background Release of endogenous proinflammatory cytokines …

Background—Obesity and diabetes mellitus are independently associated with the
development of heart failure. In this study, we determined the respective effects of obesity,
insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial …