A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …

The T-type calcium channel Cav3. 2 emerges as a key regulator of sensory functions, but its
expression pattern within primary afferent neurons and its contribution to modality-specific
signaling remain obscure. Here, we elucidate this issue using a unique knockin/flox mouse …

In vivo non-linear optical microscopy has been essential to advance our knowledge of how
intact biological systems work. It has been particularly enabling to decipher fast
spatiotemporal cellular dynamics in neural networks. The power of the technique stems from …

Studies of tissue remodeling require in vivo imaging techniques that are as minimally
invasive as possible to avoid microenvironment perturbations. To this end, spontaneous
Raman techniques have been used but low signals have limited their application mostly to …

In vivo imaging of cellular dynamics can be dramatically enabling to understand the
pathophysiology of nervous system diseases. To fully exploit the power of this approach, the
main challenges have been to minimize invasiveness and maximize the number of …

Gamma‐aminobutyric acid type B receptors (GABAB) are G‐protein‐coupled receptors that
mediate GABAergic inhibition in the brain. Their functional expression is dependent upon
the formation of heterodimers between GABAB1 and GABAB2 subunits, a process that …

Pain is a quite frequent complaint accompanying numerous pathologies. Among these
pathological cases, neuropathies are retrieved with identified etiologies (chemotherapies,
diabetes, surgeries…) and also more diffuse syndromes such as fibromyalgia. More broadly …

Hyperactivity of the glutamatergic system is involved in the development of central
sensitization in the pain neuraxis, associated with allodynia and hyperalgesia observed in
patients with chronic pain. Herein we study the ability of type 4 metabotropic glutamate …

In the central nervous system, the inhibitory GABAB receptor is the archetype of
heterodimeric G protein‐coupled receptors (GPCRs). However, the regulation of GABAB
dimerization, and more generally of GPCR oligomerization, remains largely unknown. We …

The fine-tuning of neuronal excitability relies on a tight control of Ca2+ homeostasis. The low
voltage-activated T-type calcium channels (Cav3. 1, Cav3. 2 and Cav3. 3 isoforms) play a
critical role in regulating these processes. Despite their wide expression throughout the …