About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To
identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were
analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had …

The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4
complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions
of 9p21–p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic …

We recently identified a novel tumor-suppressor gene, DPC4, at chromosome 18q21. 1 and
found that both alleles of DPC4 were inactivated in nearly one-half of the pancreatic
carcinomas. Here, we analyzed 338 tumors, originating from 12 distinct anatomic sites, for …

During tumorigenesis, positive selection is exerted upon those tumor cells that alter rate-
limiting regulatory pathways. A corollary of this principle is that mutation of one gene
abrogates the need for alteration of another gene in the same pathway and also that the …

The Rb/p16 tumor-suppressive pathway is abrogated frequently in human tumors, either
through inactivation of the Rb or p16 INK4a/CDKN2/MTS1 tumor-suppressor proteins, or
through alteration or overexpression of the cyclin D1 or cyclin-dependent kinase 4 …

Chromosome deletions are the most common genetic events observed in cancer 1–4. These
deletions are generally thought to reflect the existence of a tumour suppressor gene within
the lost region 5. However, when the lost region does not precisely coincide with a …

Background: Although as many as 10% of pancreatic cancer cases may have an inherited
component, familial pancreatic cancer has not been linked to defects in any specific gene.
Some studies have shown that families with germline mutations in the breast cancer …

Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States.
Mutations in the K-ras oncogene occur in 85% of pancreatic adenocarcinomas and have
also been identified in 75% of pancreatic ducts with mucinous cell hyperplasia seen in …

Abstract p53 and MTS1 are known to be mutationally inactivated in pancreatic
adenocarcinoma. Other tumor suppressor genes are likely also to play a role. To define
chromosomal arms which may harbor additional tumor suppressor genes, we performed an …

Smad4/DPC4 (deleted in pancreatic carcinoma, locus 4) is a tumor suppressor gene lost at
high frequency in cancers of the pancreas and other gastrointestinal organs. Smad4
encodes a key intracellular messenger in the transforming growth factor β (TGF-β) signaling …