The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

Background Malaria, an Anopheles-borne parasitic disease, remains a major global health
problem causing illness and death that disproportionately affects developing countries.
Despite the incidence of malaria, which remains one of the most severe infections of human …

Apicomplexan parasites have an assortment of unique apical secretory organelles (rhoptries
and micronemes), which have crucial functions in host infection. Here, we show that a
Toxoplasma gondii sortilin-like receptor (TgSORTLR) is required for the subcellular …

In Toxoplasma gondii, cis-acting elements present in promoter sequences of genes that are
stage-specifically regulated have been described. However, the nuclear factors that bind to
these cis-acting elements and regulate promoter activities have not been identified. In the …

Molecular mechanisms controlling gene expression in apicomplexan parasites remain
poorly understood. Here, we report the characterization of two Toxoplasma gondii homologs
of the ancient archeal Alba proteins named TgAlba1 and TgAlba2. The targeted disruption of …

Background Apicomplexan parasites are responsible for some of the most deadly parasitic
diseases afflicting humans, including malaria and toxoplasmosis. These obligate
intracellular parasites exhibit a complex life cycle and a coordinated cell cycle-dependant …

Background & Aims The innate immune system responds not only to bacterial signals, but
also to non-infectious danger-associated molecular patterns that activate the NLRP3
inflammasome complex after tissue injury. Immune functions vary over the course of the day …

The active enantiomer of tritiated quinuclidinyl benzilate (3H (‐) QNB) was used as a ligand
to evaluate the muscarinic receptors. The 3H (‐) QNB binding characteristics of muscarinic
cholinergic receptors obtained from normal and neoplastic tissues were studied to …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also
an important regulator of skeletal muscle mitochondrial biogenesis and function, and …

Background Transcatheter aortic valve replacement (TAVR) is standard therapy for patients
with severe aortic stenosis who are at high surgical risk. However, national data regarding
procedural characteristics and clinical outcomes over time are limited. Objectives The aim of …