Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy
E Woldt, Y Sebti, LA Solt, C Duhem, S Lancel… - Nature medicine, 2013 - nature.com
The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …
Mitochondrial proliferation during apoptosis induced by anticancer agents: effects of doxorubicin and mitoxantrone on cancer and cardiac cells
J Kluza, P Marchetti, MA Gallego, S Lancel, C Fournier… - Oncogene, 2004 - nature.com
Doxorubicin is one of the most largely prescribed antitumor drug for the treatment of breast,
liver and colon cancers as well as leukemia, but the cardiotoxicity of this anthracycline
derivative limits its clinical use. Although doxorubicin is toxic to both cancer and cardiac …
liver and colon cancers as well as leukemia, but the cardiotoxicity of this anthracycline
derivative limits its clinical use. Although doxorubicin is toxic to both cancer and cardiac …
Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
S Lancel, SM Hassoun, R Favory, B Decoster… - … of Pharmacology and …, 2009 - ASPET
Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in
biological systems have emerged as a potential adjunctive therapy for sepsis via their
antioxidant, anti-inflammatory, and antiapoptotic effects. The role of CO in regulation of …
biological systems have emerged as a potential adjunctive therapy for sepsis via their
antioxidant, anti-inflammatory, and antiapoptotic effects. The role of CO in regulation of …
Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality
J Larche, S Lancel, SM Hassoun, R Favory… - Journal of the …, 2006 - onlinejacc.org
Objectives The purpose of this study was to test whether mitochondrial dysfunction is
causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation
and perforation. Inhibition of mitochondrial permeability transition was achieved by means of …
causative of sepsis sequelae, a mouse model of peritonitis sepsis induced by cecal ligation
and perforation. Inhibition of mitochondrial permeability transition was achieved by means of …
[CITATION][C] Ventricular myocyte caspases are directly responsible for endotoxin-induced cardiac dysfunction
S Lancel, O Joulin, R Favory, JF Goossens, J Kluza… - Circulation, 2005 - Am Heart Assoc
Nitroxyl activates SERCA in cardiac myocytes via glutathiolation of cysteine 674
S Lancel, J Zhang, A Evangelista, MP Trucillo… - Circulation …, 2009 - Am Heart Assoc
Nitroxyl (HNO) exerts inotropic and lusitropic effects in myocardium, in part via activation of
SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the molecular mechanism,
adult rat ventricular myocytes were exposed to HNO derived from Angeli's salt. HNO …
SERCA (sarcoplasmic reticulum calcium ATPase). To elucidate the molecular mechanism,
adult rat ventricular myocytes were exposed to HNO derived from Angeli's salt. HNO …
Peroxynitrite decomposition catalysts prevent myocardial dysfunction and inflammation in endotoxemic rats
S Lancel, S Tissier, S Mordon, X Marechal… - Journal of the …, 2004 - onlinejacc.org
Objectives The aim of this study was to test whether peroxynitrite neutralizers would reduce
peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation
in endotoxin-treated rats. Background Release of endogenous proinflammatory cytokines …
peroxynitrite accumulation and improve myocardial contractile dysfunction and inflammation
in endotoxin-treated rats. Background Release of endogenous proinflammatory cytokines …
Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes
GM Kuster, S Lancel, J Zhang, C Communal… - Free Radical Biology …, 2010 - Elsevier
Myocardial failure is associated with increased oxidative stress and abnormal excitation–
contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca 2+ stores
and a reduction in Ca 2+-transient amplitude. Little is known about the mechanisms …
contraction coupling characterized by depletion of sarcoplasmic reticulum (SR) Ca 2+ stores
and a reduction in Ca 2+-transient amplitude. Little is known about the mechanisms …
Novelty and Significance
Background: Myocyte contractile dysfunction occurs in pathological remodeling in
association with abnormalities in calcium regulation. Mice with cardiac myocyte–specific
overexpression of Gαq develop progressive left ventricular failure associated with myocyte …
association with abnormalities in calcium regulation. Mice with cardiac myocyte–specific
overexpression of Gαq develop progressive left ventricular failure associated with myocyte …
NADPH oxidases participate to doxorubicin-induced cardiac myocyte apoptosis
…, D Montaigne, J Franczak, R Neviere, S Lancel - Biochemical and …, 2009 - Elsevier
Cumulative doses of doxorubicin, a potent anticancer drug, lead to serious myocardial
dysfunction. Numerous mechanisms including apoptosis have been proposed to account for
its cardiotoxicity. Cardiac apoptosis induced by doxorubicin has been related to excessive …
dysfunction. Numerous mechanisms including apoptosis have been proposed to account for
its cardiotoxicity. Cardiac apoptosis induced by doxorubicin has been related to excessive …
