CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the
formation of Ca 2+ signalling molecules, but its role in the neuroendocrine system is
unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show …

Previous gene knockout studies have shown that the orphan glutamate receptor δ2
(GluRδ2) is critically involved in synaptogenesis between parallel fibers and Purkinje cells
during development. However, the precise function of GluRδ2 and whether it is functional in …

Polyglutamine disorders are inherited neurodegenerative diseases caused by the
accumulation of expanded polyglutamine protein (polyQ). Previously, we identified a new
guanosine triphosphatase, CRAG, which facilitates the degradation of polyQ aggregates …

Cerebellar Purkinje cells are key elements in motor learning and motor coordination, and
therefore, it is important to clarify the mechanisms by which Purkinje cells integrate
information and control cerebellar function. Gene transfer into neurons, followed by the …

Here, we show that cultured Purkinje cells from inositol 1, 4, 5-trisphosphate receptor type 1
knock-out (IP 3 R1KO) mice exhibited abnormal dendritic morphology. Interestingly, despite
the huge amount of IP 3 R1 expression in Purkinje cells, IP 3 R1 in granule cells, not in the …

The orphan glutamate receptor δ2 is selectively expressed in Purkinje cells and plays a
crucial role in cerebellar functions. Recently, ataxia in the hotfoot mouse ho4J was
demonstrated to be caused by a deletion in the δ2 receptor gene (Grid2) removing the N …

Cerebellar Purkinje cells play an important role in cerebellar function; lesions of Purkinje
cells result in the disruption of motor coordination and motor learning. Although selective
gene delivery to Purkinje cells would be a powerful technique for the study of …

The immune and nervous systems display considerable overlap in their molecular
repertoire. Molecules originally shown to be critical for immune responses also serve
neuronal functions that include normal brain development, neuronal differentiation, synaptic …

Viral-vector-mediated gene delivery into Purkinje cells is a promising method for exploring
the pathophysiology of the cerebellum; however, it is generally difficult to achieve sufficiently
high levels of gene expression in Purkinje cells using viral vectors with a cell-type-specific …

The present invention provides a pharmaceutical composition for human cytomegalovirus
HCMV causative of various disease states, the composition comprising a monoclonal
antibody and an antigen-binding fragment thereof that specifically binds to the AD1 region of …