Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl− homeostasis
F Ferrini, T Trang, TAM Mattioli, S Laffray… - Nature …, 2013 - nature.com
A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …
[HTML][HTML] Ultra-low dose naltrexone attenuates chronic morphine-induced gliosis in rats
TAM Mattioli, B Milne, CM Cahill - Molecular pain, 2010 - molecularpain.biomedcentral.com
The development of analgesic tolerance following chronic morphine administration can be a
significant clinical problem. Preclinical studies demonstrate that chronic morphine
administration induces spinal gliosis and that inhibition of gliosis prevents the development …
significant clinical problem. Preclinical studies demonstrate that chronic morphine
administration induces spinal gliosis and that inhibition of gliosis prevents the development …
[HTML][HTML] Toll-like receptor 4 mutant and null mice retain morphine-induced tolerance, hyperalgesia, and physical dependence
TA Mattioli, H Leduc-Pessah, G Skelhorne-Gross… - PloS one, 2014 - journals.plos.org
The innate immune system modulates opioid-induced effects within the central nervous
system and one target that has received considerable attention is the toll-like receptor 4
(TLR4). Here, we examined the contribution of TLR4 in the development of morphine …
system and one target that has received considerable attention is the toll-like receptor 4
(TLR4). Here, we examined the contribution of TLR4 in the development of morphine …
Intrathecal catheterization influences tolerance to chronic morphine in rats
TA Mattioli, M Sutak, B Milne, K Jhamandas… - Anesthesia & …, 2012 - journals.lww.com
METHODS Experiments, complying with Canadian Council on Animal Care policies, were
approved by the Queen's University Animal Care Committee. Male Sprague-Dawley rats
(200–250 g) were housed individually with ad libitum access to food and water, and …
approved by the Queen's University Animal Care Committee. Male Sprague-Dawley rats
(200–250 g) were housed individually with ad libitum access to food and water, and …
