A major unresolved issue in treating pain is the paradoxical hyperalgesia produced by the
gold-standard analgesic morphine and other opiates. We found that hyperalgesia-inducing
treatment with morphine resulted in downregulation of the K+-Cl− co-transporter KCC2 …

OBJECTIVE During diabetes, retinal microglial cells are activated to release inflammatory
cytokines that initiate neuronal loss and blood–retinal barrier breakdown seen in diabetic
retinopathy (DR). The mechanism by which diabetes activates microglia to release those …

China is the world's largest producer, consumer, processor, and exporter of finfish and
shellfish (defined here as “fish”), and its fish imports are steadily rising (1–3). China
produces more than one-third of the global fish supply, largely from its ever-expanding …

Rationale: The heterotypic interactions of endothelial cells and mural cells (smooth muscle
cells or pericytes) are crucial for assembly, maturation, and subsequent function of blood
vessels. Yet, the molecular mechanisms underlying their association have not been fully …

Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a
leading cause of blindness in people of the working age in Western countries. A major
pathology of DR is microvascular complications suchas non-perfused vessels …

Shear-wave velocities (VS) are widely used for earthquake ground-motion site
characterization. VS data are now largely obtained using borehole methods. Drilling holes,
however, is expensive. Nonintrusive surface methods are inexpensive for obtaining VS …

The present disclosure relates to playback of video/audio streaming media data to provide a
substantially glitch-free experience. The system adapts the media stream to the user
connection in order to choose the most desirable stream to avoid glitches. For example, in …

Production of nanomaterials is becoming increasingly important as a result of diverse
industrial applications. Nanomaterials can be prepared by a dry process or a wet process;
the latter involves drying, which affects the quality of the products. This article presents an …

The present disclosure relates to playback of video/audio streaming media data to provide a
glitch-free experience. The system adapts the media stream to the user connection in order
to provide the glitch-free experience. Stream selection can be made using a heuristics …

Event-related magnetic fields were recorded using magnetoencephalography in children
with (n= 12) and without (n= 11) dyslexia while they discriminated between pairs of syllables
from a voice onset time series (/ga/-/ka/). Nonimpaired readers exhibited left-hemisphere …