Molecular self-assembly offers a 'bottom-up'route to fabrication with subnanometre precision
of complex structures from simple components 1. DNA has proved to be a versatile building
block 2, 3, 4, 5 for programmable construction of such objects, including two-dimensional …

Molecular self-assembly offers a means of spontaneously forming complex and well-defined
structures from simple components. The specific bonding between DNA base pairs has
been used in this way to create DNA-based nanostructures and to direct the assembly of …

We demonstrate the ability to engineer complex shapes that twist and curve at the
nanoscale from DNA. Through programmable self-assembly, strands of DNA are directed to
form a custom-shaped bundle of tightly cross-linked double helices, arrayed in parallel to …

DNA molecules have been used to build a variety of nanoscale structures and devices over
the past 30 years, and potential applications have begun to emerge. But the development of
more advanced structures and applications will require a number of issues to be addressed …

We describe a simple and robust method to construct complex three-dimensional (3D)
structures by using short synthetic DNA strands that we call “DNA bricks.” In one-step
annealing reactions, bricks with hundreds of distinct sequences self-assemble into …

DNA nanotechnology exploits the programmable specificity afforded by base-pairing to
produce self-assembling macromolecular objects of custom shape. For building megadalton-
scale DNA nanostructures, a long 'scaffold'strand can be employed to template the assembly …

Membrane proteins are encoded by 20–35% of genes but represent< 1% of known protein
structures to date. Thus, improved methods for membrane-protein structure determination
are of critical importance. Residual dipolar couplings (RDCs), commonly measured for …

Abstract Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the
mitochondrial anion carrier protein family, the members of which facilitate the transport of
small molecules across the mitochondrial inner membrane 1, 2. When the mitochondrial …

Super-resolution fluorescence microscopy is a powerful tool for biological research, but
obtaining multiplexed images for a large number of distinct target species remains
challenging. Here we use the transient binding of short fluorescently labeled …

Tensegrity, or tensional integrity, is a property of a structure indicating a reliance on a
balance between components that are either in pure compression or pure tension for
stability 1, 2. Tensegrity structures exhibit extremely high strength-to-weight ratios and great …