Rationale: A crucial step in atherogenesis is the infiltration of the subendothelial space of
large arteries by monocytes where they differentiate into macrophages and transform into
lipid-loaded foam cells. Macrophages are heterogeneous cells that adapt their response to …

The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism,
adipogenesis and the inflammatory response in macrophages. We show here that Rev-erb-
α is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to …

Background—Obesity and diabetes mellitus are independently associated with the
development of heart failure. In this study, we determined the respective effects of obesity,
insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial …

The role of the nonclassical human leukocyte antigen (HLA) class Ib molecule HLA-G in
immune tolerance was first reported at maternofetal interface. This immunomodulating role
could be exerted more generally in tumoral or post-transplantation situations in inhibiting …

Human leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes
of the major histocompatibility complex exhibit immunomodulatory properties. They are
either membrane-bound or solubly expressed during certain tumoral malignancies. Soluble …

HLA‐G molecules are known to exert immunosuppressive action on DC maturation and on
NK cells, and can in consequence inhibit respectively T cell responses and NK cytolysis. In
this study, we show that monocyte‐derived DC, differentiated in the presence of GM‐CSF …

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and
the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen
and decrease intestinal FXR activity. The BAS–BA complex also induces glucagon-like …

Membrane‐bound and soluble human leucocyte antigen‐G (sHLA‐G) molecules display
immunotolerant properties favouring tumour cell escape from immune surveillance. sHLA‐G
molecules have been detected in several tumour pathologies; this study aimed to evaluate …

The immunomodulatory properties of soluble human leukocyte antigen G (sHLA-G) explain
its potential interest in malignancies. HLA-G frequently transcribed in lymphoproliferative
disorders is rarely expressed at cell surface. In this article, we will demonstrate that the …

The immunomodulatory properties of the HLA-G molecule explain its relevance in
malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and
variable distribution of alternatively spliced HLA-G mRNA isoforms,(ii) a rare cell surface …