Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture 1, 2, 3, 4. We report here a comprehensive analysis of
transcriptome dynamics from oocyte to morula in both human and mouse embryos, using …

Poly (ethylene oxide)(PEO) based materials are widely considered as promising candidates
of polymer hosts in solid-state electrolytes for high energy density secondary lithium
batteries. They have several specific advantages such as high safety, easy fabrication, low …

Recent advances in gene editing technology have introduced the potential for application of
mutagenesis approaches in nonhuman primates to model human development and
disease. Here we report successful TALEN-mediated mutagenesis of an X-linked, Rett …

DNA methylation is a major epigenetic factor regulating genome reprogramming, cell
differentiation and developmental gene expression. To understand the role of DNA
methylation in central nervous system (CNS) neurons, we generated conditional Dnmt1 …

Over half of coal in China is burned directly by power plants, becoming an important source
of hazardous trace element emissions, such as mercury (Hg), arsenic (As), and selenium
(Se), etc. Based on coal consumption by each power plant, emission factors classified by …

Development of reliable vectors is a major challenge in gene therapy. Previous gene
transfer methods using non-viral vectors, such as liposomes or nanoparticles, have resulted
in relatively low levels (35∼ 50%) of gene expression. We have developed a silicon …

Living polymers: Iron (III) complexes with phosphorus‐containing ligands are efficient
catalysts for atom transfer radical polymerization in the absence of any radical initiator or
reducing agent. The polymers produced have good molecular weights and narrow …

Abstract Recent studies in desmin (−/−) mice have shown that the targeted ablation of
desmin leads to pathological changes of the extrasarcomeric intermediate filament
cytoskeleton, as well as structural and functional abnormalities of mitochondria in striated …

The pyridylphosphine ligand, 2-(diphenylphosphino) pyridine (DPPP), was employed in the
iron (III)-catalyzed atom transfer radical polymerizations (ATRPs) of methyl methacrylate
(MMA) with various initiators and solvents in the absence of any radical initiators or reducing …

A recently identified class of myopathies is produced by abnormal desmin, and is
characterized by a disorganization of the desmin filament network, the accumulation of
insoluble desmin‐containing aggregates, and destructive changes in the sarcomeric …