… that CB1 mediates most or all supraspinal effects of marijuana, and consistent with this, Δ 9
-THC–stimulated [ 3 H]GTPγS binding is abolished in the brains of CB1 −/− mice (8). A second
G protein–coupled cannabinoid receptor (CB2) appears to be absent from the brain but is …

Anandamide [arachidonylethanolamide (AEA)] appears to be an endogenous agonist of
brain cannabinoid receptors (CB1), yet some of the neurobehavioral effects of this
compound in mice are unaffected by a selective CB1 antagonist. We studied the levels …

The presence of central cannabinoid receptor (CB 1), involving the N-terminal 14 amino acid
peptide, was demonstrated in the rat brain by immunohistochemistry. Intensely stained
neurons were observed in the principal neurons of the hippocampus, striatum, substantia …

CB1–type cannabinoid receptors in the brain mediate effects of the drug cannabis.
Anandamide and sn–2 arachidonylglycerol (2–AG) are putative endogenous ligands for
CB1 receptors, but it is not known which cells in the brain produce these molecules …

The CB1‐type cannabinoid receptor mediates physiologic effects of Δ9‐
tetrahydrocannabinol, the psychoactive ingredient of the drug marijuana. In this report, the
authors analyse the expression of CB1 in the rat brain by using antibodies to the C‐terminal …

We have investigated the binding of 123 I-labeled N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-
dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251), an analog of the
cannabinoid receptor antagonist SR141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4 …

Background: Although CB 1, the most abundant neuronal receptors, and CB 2 receptors are
co-expressed in neurons, the CB 1-CB 2 relationship is unknown. Results: CB 1 and CB 2
receptors form heteromers in neuronal cells and in the brain. Conclusion: Activation of either …

The immunohistochemical distribution and subcellular localization of the cannabinoid CB1
receptor was determined in the adult monkey using a polyclonal antiserum raised against
the amino terminus of the rat CB1 receptor. At the level of light microscopy, our results …

There is a general consensus that the effects of cannabinoid agonists on anxiety seem to be
biphasic, with low doses being anxiolytic and high doses ineffective or possibly anxiogenic.
Besides the behavioural effects of cannabinoids on anxiety, very few papers have dealt with …

SR 141716A belongs to a new class of compounds (diarylpyrazole) that inhibits brain
carmabinoid receptors (CB1) in vitro and in vivo. The present study showed that [3 H]-SR
141716A binds with high affinity (K d= 0.61±0.06 nM) to a homogenous population of …