| LRRK2 kinase in Parkinson's disease DR Alessi, E Sammler Science 360 (6384), 36-37, 2018 | 266 | 2018 |
| Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression RM Hines, L Wu, DJ Hines, H Steenland, S Mansour, R Dahlhaus, X Cao, ... Journal of Neuroscience 28 (24), 6055-6067, 2008 | 210 | 2008 |
| The Parkinson's disease VPS35 [D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human R Mir, F Tonelli, P Lis, T Macartney, NK Polinski, TN Martinez, MY Chou, ... Biochemical Journal 475 (11), 1861-1883, 2018 | 181 | 2018 |
| Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils Y Fan, AJM Howden, AR Sarhan, P Lis, G Ito, TN Martinez, K Brockmann, ... Biochemical Journal 475 (1), 23-44, 2018 | 151 | 2018 |
| A harmless high? EM Sammler, PL Foley, GD Lauder, SJ Wilson, AR Goudie, JI O'Riordan The Lancet 376 (9742), 742, 2010 | 80 | 2010 |
| Discovery of XL01126: a potent, fast, cooperative, selective, orally bioavailable, and blood–brain barrier penetrant PROTAC degrader of leucine-rich repeat kinase 2 X Liu, AF Kalogeropulou, S Domingos, N Makukhin, RS Nirujogi, F Singh, ... Journal of the American Chemical Society 144 (37), 16930-16952, 2022 | 68 | 2022 |
| Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease Ö Karayel, F Tonelli, SV Winter, PE Geyer, Y Fan, EM Sammler, DR Alessi, ... Molecular & Cellular Proteomics 19 (9), 1546-1560, 2020 | 60 | 2020 |
| R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils Y Fan, RS Nirujogi, A Garrido, J Ruiz-Martínez, A Bergareche-Yarza, ... Acta Neuropathologica 142 (3), 475-494, 2021 | 48 | 2021 |
| Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding AF Kalogeropulou, E Purlyte, F Tonelli, SM Lange, M Wightman, ... Biochemical Journal 479 (17), 1759-1783, 2022 | 47 | 2022 |
| Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites RS Nirujogi, F Tonelli, M Taylor, P Lis, A Zimprich, E Sammler, DR Alessi Biochemical Journal 478 (2), 299-326, 2021 | 43 | 2021 |
| AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions A Meyer, G Hilgen, B Dorgau, EM Sammler, R Weiler, H Monyer, K Dedek, ... Journal of cell science 127 (6), 1190-1202, 2014 | 39 | 2014 |
| Alterations of red cell membrane properties in nneuroacanthocytosis C Siegl, P Hamminger, H Jank, U Ahting, B Bader, A Danek, A Gregory, ... PLoS One 8 (10), e76715, 2013 | 34 | 2013 |
| In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse I Helbig, E Sammler, M Eliava, AP Bolshakov, A Rozov, R Bruzzone, ... Molecular and Cellular Neuroscience 45 (1), 47-58, 2010 | 34 | 2010 |
| Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport? S Titz, EM Sammler, SG Hormuzdi Neuropharmacology 95, 321-331, 2015 | 31 | 2015 |
| Embracing monogenic Parkinson's disease: the MJFF Global Genetic PD cohort EJ Vollstedt, S Schaake, K Lohmann, S Padmanabhan, A Brice, S Lesage, ... Movement Disorders 38 (2), 286-303, 2023 | 19 | 2023 |
| The commercial genetic testing landscape for Parkinson's disease L Cook, J Schulze, J Verbrugge, JC Beck, KS Marder, ... Parkinsonism & related disorders 92, 107-111, 2021 | 17 | 2021 |
| Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson’s disease-associated GBA gene M Toffoli, X Chen, FJ Sedlazeck, CY Lee, S Mullin, A Higgins, S Koletsi, ... Communications Biology 5 (1), 670, 2022 | 16 | 2022 |
| LRP10 interacts with SORL1 in the intracellular vesicle trafficking pathway in non-neuronal brain cells and localises to Lewy bodies in Parkinson’s disease and dementia with … MM Grochowska, A Carreras Mascaro, V Boumeester, D Natale, ... Acta Neuropathologica 142 (1), 117-137, 2021 | 16 | 2021 |
| A blood-based marker of mitochondrial DNA damage in Parkinson’s disease R Qi, E Sammler, CP Gonzalez-Hunt, I Barraza, N Pena, JP Rouanet, ... Science translational medicine 15 (711), eabo1557, 2023 | 12 | 2023 |
| Human peripheral blood neutrophil isolation for interrogating the Parkinson's associated LRRK2 kinase pathway by assessing Rab10 phosphorylation Y Fan, F Tonelli, S Padmanabhan, MAS Baptista, L Riley, D Smith, ... JoVE (Journal of Visualized Experiments), e58956, 2020 | 12 | 2020 |
Dario AlessiMRC Protein Phosphorylation and Ubiquitylation Units, University of DundeeVerified email at dundee.ac.uk
