Simon Newstead
Simon Newstead
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Overcoming barriers to membrane protein structure determination
RM Bill, PJF Henderson, S Iwata, ERS Kunji, H Michel, R Neutze, ...
Nature biotechnology 29 (4), 335-340, 2011
GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae
D Drew, S Newstead, Y Sonoda, H Kim, G Von Heijne, S Iwata
Nature protocols 3 (5), 784-798, 2008
Molecular basis of nitrate uptake by the plant nitrate transporter NRT1. 1
JL Parker, S Newstead
Nature 507 (7490), 68-72, 2014
Structural basis of Smoothened regulation by its extracellular domains
EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ...
Nature 535 (7613), 517-522, 2016
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide–proton symporters, PepT1 and PepT2
S Newstead, D Drew, AD Cameron, VLG Postis, X Xia, PW Fowler, ...
The EMBO journal 30 (2), 417-426, 2011
Membrane protein structure determination—the next generation
I Moraes, G Evans, J Sanchez-Weatherby, S Newstead, PDS Stewart
Biochimica et Biophysica Acta (BBA)-Biomembranes 1838 (1), 78-87, 2014
High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae
S Newstead, H Kim, G von Heijne, S Iwata, D Drew
Proceedings of the National Academy of Sciences 104 (35), 13936-13941, 2007
MemProtMD: automated insertion of membrane protein structures into explicit lipid membranes
PJ Stansfeld, JE Goose, M Caffrey, EP Carpenter, JL Parker, S Newstead, ...
Structure 23 (7), 1350-1361, 2015
A two-domain elevator mechanism for sodium/proton antiport
C Lee, HJ Kang, C Von Ballmoos, S Newstead, P Uzdavinys, DL Dotson, ...
Nature 501 (7468), 573-577, 2013
Alternating access mechanism in the POT family of oligopeptide transporters
N Solcan, J Kwok, PW Fowler, AD Cameron, D Drew, S Iwata, ...
The EMBO journal 31 (16), 3411-3421, 2012
Structural basis for dynamic mechanism of proton-coupled symport by the peptide transporter POT
S Doki, HE Kato, N Solcan, M Iwaki, M Koyama, M Hattori, N Iwase, ...
Proceedings of the National Academy of Sciences 110 (28), 11343-11348, 2013
Rationalizing α‐helical membrane protein crystallization
S Newstead, S Ferrandon, S Iwata
Protein Science 17 (3), 466-472, 2008
Benchmarking membrane protein detergent stability for improving throughput of high-resolution X-ray structures
Y Sonoda, S Newstead, NJ Hu, Y Alguel, E Nji, K Beis, S Yashiro, C Lee, ...
Structure 19 (1), 17-25, 2011
The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates
SL Newstead, JA Potter, JC Wilson, G Xu, CH Chien, AG Watts, ...
Journal of Biological Chemistry 283 (14), 9080-9088, 2008
Crystal structures of a double-barrelled fluoride ion channel
RB Stockbridge, L Kolmakova-Partensky, T Shane, A Koide, S Koide, ...
Nature 525 (7570), 548-551, 2015
Structural basis for pH-dependent retrieval of ER proteins from the Golgi by the KDEL receptor
P Bräuer, JL Parker, A Gerondopoulos, I Zimmermann, MA Seeger, ...
Science 363 (6431), 1103-1107, 2019
Molecular insights into proton coupled peptide transport in the PTR family of oligopeptide transporters
S Newstead
Biochimica Et Biophysica Acta (BBA)-General Subjects 1850 (3), 488-499, 2015
Structural basis for amino acid transport by the CAT family of SLC7 transporters
KEJ Jungnickel, JL Parker, S Newstead
Nature communications 9 (1), 550, 2018
Structural basis for polyspecificity in the POT family of proton‐coupled oligopeptide transporters
JA Lyons, JL Parker, N Solcan, A Brinth, D Li, STA Shah, M Caffrey, ...
EMBO reports 15 (8), 886-893, 2014
Generation of synthetic nanobodies against delicate proteins
I Zimmermann, P Egloff, CAJ Hutter, BT Kuhn, P Bräuer, S Newstead, ...
Nature protocols 15 (5), 1707-1741, 2020
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